skin aging

By Targets:	Akt (1) Angiotensin-converting Enzyme (ACE) (1) AP-1 (1) Apoptosis (2) Autophagy (1) Bacterial (2) Casein Kinase (1) Caspase (2) CFTR (1) Endogenous Metabolite (2) Glucosidase (1) Keap1-Nrf2 (1) MMP (1) p38 MAPK (2) PARP (1) PI3K (1) Tyrosinase (1) VEGFR (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Endocrinology (1) Infection (2) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3127

Orobol	Casein Kinase PI3K VEGFR	Metabolic Disease
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) .

HY-P0095

Acetyl tetrapeptide-5	Angiotensin-converting Enzyme (ACE)	Others
Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care .

HY-N3612

Communic acid (+)-Communic acid	Bacterial Akt MMP	Infection Inflammation/Immunology
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging .

HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

Logmalicid B	Others	Metabolic Disease
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-N1190

DL-Syringaresinol (±)-Syringaresinol	p38 MAPK AP-1 Bacterial	Infection
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv .

HY-N2278

Kushenol A 1 Publications Verification Leachianone E	Tyrosinase Glucosidase	Cancer
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .

HY-N0568

Madecassoside Asiaticoside A	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase	Cardiovascular Disease Others Neurological Disease Inflammation/Immunology Endocrinology Cancer
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-N6818

5,7,4'-Trimethoxyflavone	Apoptosis Caspase PARP Endogenous Metabolite CFTR	Cancer
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

Cat. No.	Product Name	Target	Research Area

HY-P3163

Hexapeptide-9	Peptides	Others
Hexapeptide-9 is a collagen peptide, with anti-aging activity. Hexapeptide-9 is commonly used as the ingredient in skin care products for improving the appearance of the skin .

HY-P0095

Acetyl tetrapeptide-5	Angiotensin-converting Enzyme (ACE)	Others
Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care .

HY-A0299

H-Gly-Pro-Hyp-OH Tripeptide 29	Peptides	Others
HGly-Pro-Hyp-OH (Tripeptide 29) is an orally active bioactive peptide against UVB-induced skin aging and has been reported used as a cosmetic ingredient ^[1]

HY-P5237

Tetrapeptide-4	Peptides	Others
Tetrapeptide-4 is a peptide ingredient commonly used in skin care products to reduce wrinkles, strengthen collagen, elastin and fibronectin, and possess powerful anti-aging properties .

HY-P5221

Acetyl hexapeptide-37

Peptides Others

Acetyl hexapeptide-37 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

Acetyl hexapeptide-37	Peptides	Others
Acetyl hexapeptide-37 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-P0033

Argireline Acetyl hexapeptide-3	Peptides	Neurological Disease
Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity .

HY-P0033A

Argireline acetate Acetyl hexapeptide-3 acetate	Peptides	Neurological Disease
Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity .

HY-P3164

Acetyl tetrapeptide-9

AcTP1
Peptides Others

Caprooyl-tetrapeptide-9 (AcTP1) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

Acetyl tetrapeptide-9 AcTP1	Peptides	Others
Caprooyl-tetrapeptide-9 (AcTP1) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3127

Orobol	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Isoflavones	Casein Kinase PI3K VEGFR
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) .

HY-N2278

Kushenol A 1 Publications Verification Leachianone E	Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Cancer	Tyrosinase Glucosidase
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .

HY-N3612

Communic acid (+)-Communic acid	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial Akt MMP
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging .

HY-N12840

Logmalicid B	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-N1190

DL-Syringaresinol (±)-Syringaresinol	Structural Classification Source classification Lignans Phenylpropanoids Plants Lauraceae Lindera akoensis Hay.	p38 MAPK AP-1 Bacterial
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv .

HY-N0568

Madecassoside Asiaticoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Tagetes lucida Cav. Plants Umbelliferae Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-N6818

5,7,4'-Trimethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Cancer Zingiberaceae	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

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